On the Alert for Cytokine Storm: Immunopathology in  COVID ‐19

Henderson, Lauren A.; Canna, Scott; Schulert, Grant S.; Volpi, Stefano; Lee, Pui Y.; Kernan, Kate F.; Caricchio, Roberto; Mahmud, Shawn A.; Hazen, Melissa M.; Halyabar, Olha; Hoyt, Kacie J.; Han, Joseph; Grom, Alexei A.; Gattorno, Marco; Ravelli, Angelo; Benedetti, Fabrizio De; Behrens, Edward M.; Cron, Randy Q.; Nigrović, Peter A.

doi:10.1002/art.41285

articleArthritis & RheumatologyApr 15, 2020BRONZE OA

On the Alert for Cytokine Storm: Immunopathology in COVID ‐19

LALauren A. Henderson SCScott Canna GSGrant S. Schulert SVStefano Volpi PYPui Y. Lee

Boston Children's Hospital · Harvard University · +16 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Poor outcomes in COVID-19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapolating from clinical experience in cytokine storm syndromes may benefit the multidisciplinary teams caring for patients with severe COVID-19.

Citation impact

654

total citations

FWCI: 15.42
Percentile: 100%
References: 21

Citations per year

Authors

19

Topics & keywords

Topics

Keywords

Cytokine storm
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
2019-20 coronavirus outbreak
Immunopathology
Cytokine
Betacoronavirus
Storm

UN Sustainable Development Goals

No poverty

No related works found for this paper.