Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
Sun Yat-sen University · Fifth Affiliated Hospital of Sun Yat-sen University · +3 more institutions
Abstract
The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. Currently, there is no specific viral protein-targeted therapeutics. Viral nucleocapsid protein is a potential antiviral drug target, serving multiple critical functions during the viral life cycle. However, the structural information of SARS-CoV-2 nucleocapsid protein remains unclear. Herein, we have determined the 2.7 Å crystal structure of the N-terminal RNA binding domain of SARS-CoV-2 nucleocapsid protein. Although the overall structure is similar as other reported coronavirus nucleocapsid protein N-terminal domain, the surface electrostatic potential characteristics between…
Citation impact
- FWCI
- 15.44
- Percentile
- 100%
- References
- 52
Authors
14- SKSisi Kang
Sun Yat-sen University, Fifth Affiliated Hospital of Sun Yat-sen University
- MYMei Yang
Sun Yat-sen University, Fifth Affiliated Hospital of Sun Yat-sen University
- ZHZhongsi Hong
Sun Yat-sen University, Fifth Affiliated Hospital of Sun Yat-sen University
- LZLiping Zhang
Chinese Academy of Sciences, Institute of Oceanology, South China Sea Institute Of Oceanology
- ZHZhaoxia Huang
Sun Yat-sen University, Fifth Affiliated Hospital of Sun Yat-sen University
Topics & keywords
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Coronavirus disease 2019 (COVID-19)
- RNA
- Drug
- Virology
- Binding site
- Sars virus
- RNA-binding protein