The role of long noncoding RNAs in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most frequent subtype of primary liver cancer and one of the leading causes of cancer-related death worldwide. However, the molecular mechanisms underlying HCC pathogenesis have not been fully understood. Emerging evidences have recently suggested the crucial role of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of HCC. Various HCC-related lncRNAs have been shown to possess aberrant expression and participate in cancerous phenotypes (e.g. persistent proliferation, evading apoptosis, accelerated vessel formation and gain of invasive capability) through their binding with DNA, RNA or proteins, or encoding small peptides. Thus, a deeper understanding of…

• NN
  National Natural Science Foundation of China

  Awards: 81430071 and 81672381, 81430071, 81821002, 81790251, 81430071 and 81672381, 81821002, 2013CB911300, 81672381, 81790251
• DO
  Department of Science and Technology of Sichuan Province

  Award: 2019JDTD0013
• SU
  Sichuan University

  Award: ZYJC18030
• NK
  National Key Research and Development Program of China

  Award: 2013CB911300
• FR
  Fundamental Research Funds for the Central Universities

  Award: 2018SCUH0018
• WC
  West China Hospital, Sichuan University

  Awards: ZYJC18030, 1.3.5
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2019B030302012