Type 2 immunity in the skin and lungs
University of Zurich · CK-CARE · +12 more institutions
Abstract
There has been extensive progress in understanding the cellular and molecular mechanisms of inflammation and immune regulation in allergic diseases of the skin and lungs during the last few years. Asthma and atopic dermatitis (AD) are typical diseases of type 2 immune responses. interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin are essential cytokines of epithelial cells that are activated by allergens, pollutants, viruses, bacteria, and toxins that derive type 2 responses. Th2 cells and innate lymphoid cells (ILC) produce and secrete type 2 cytokines such as IL-4, IL-5, IL-9, and IL-13. IL-4 and IL-13 activate B cells to class-switch to IgE and also play a role in T-cell and eosinophil migration to…
Citation impact
- FWCI
- 46.42
- Percentile
- 100%
- References
- 270
Authors
11- CACezmi A. AkdişCorresponding
University of Zurich, CK-CARE
- PDPeter D. Arkwright
University of Manchester, Centre for Inflammation Research
- MBMarie‐Charlotte Brüggen
University of Zurich, University Hospital of Zurich, CK-CARE
- WWWilliam W. Busse
University of Wisconsin–Madison
- MGMassimo Gadina
Office of Science, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Topics & keywords
- Thymic stromal lymphopoietin
- Immunology
- Allergic inflammation
- Eosinophil
- Innate lymphoid cell
- Immunoglobulin E
- Inflammation
- Immune system
- Good health and well-being