reviewAdvanced Drug Delivery ReviewsJan 1, 2020HYBRID OA

Extracellular vesicles as drug delivery systems: Why and how?

University Medical Center Utrecht · Karolinska Institutet · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Over the past decades, a multitude of synthetic drug delivery systems has been developed and introduced to the market. However, applications of such systems are limited due to inefficiency, cytotoxicity and/or immunogenicity. At the same time, the field of natural drug carrier systems has grown rapidly. One of the most prominent examples of such natural carriers are extracellular vesicles (EVs). EVs are cell-derived membranous particles which play important roles in intercellular communication. EVs possess a number of characteristics that qualify them as promising vehicles for drug delivery. In order to take advantage of these attributes, an in-depth understanding of why EVs are such unique carrier systems and…

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1,184
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53.51
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100%
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Authors

7

Topics & keywords

Keywords
  • Drug delivery
  • Extracellular vesicles
  • Targeted drug delivery
  • Extracellular vesicle
  • Nanotechnology
  • Exploit
  • Drug
  • Microvesicles
UN Sustainable Development Goals
  • Good health and well-being
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