Extracellular vesicles as drug delivery systems: Why and how?
University Medical Center Utrecht · Karolinska Institutet · +2 more institutions
Abstract
Over the past decades, a multitude of synthetic drug delivery systems has been developed and introduced to the market. However, applications of such systems are limited due to inefficiency, cytotoxicity and/or immunogenicity. At the same time, the field of natural drug carrier systems has grown rapidly. One of the most prominent examples of such natural carriers are extracellular vesicles (EVs). EVs are cell-derived membranous particles which play important roles in intercellular communication. EVs possess a number of characteristics that qualify them as promising vehicles for drug delivery. In order to take advantage of these attributes, an in-depth understanding of why EVs are such unique carrier systems and…
Citation impact
- FWCI
- 53.51
- Percentile
- 100%
- References
- 138
Authors
7Topics & keywords
- Drug delivery
- Extracellular vesicles
- Targeted drug delivery
- Extracellular vesicle
- Nanotechnology
- Exploit
- Drug
- Microvesicles
- Good health and well-being