Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell
Instituto de Salud Carlos III · Biomedical Research Networking Center on Neurodegenerative Diseases · +1 more institution
Abstract
Nanoparticles (NPs) and submicron particles are increasingly used as carriers for delivering therapeutic compounds to cells. Their entry into the cell represents the initial step in this delivery process, being most of the nanoparticles taken up by endocytosis, although other mechanisms can contribute to the uptake. To increase the delivery efficiency of therapeutic compounds by NPs and submicron particles is very relevant to understand the mechanisms involved in the uptake process. This review covers the proposed pathways involved in the cellular uptake of different NPs and submicron particles types as well as the role that some of the physicochemical nanoparticle characteristics play in the uptake pathway…
Citation impact
- FWCI
- 19.44
- Percentile
- 100%
- References
- 115
Authors
2- DMDarío Manzanares
Instituto de Salud Carlos III, Biomedical Research Networking Center on Neurodegenerative Diseases, University of Castilla-La Mancha
- VCValentı́n CeñaCorresponding
Instituto de Salud Carlos III, Biomedical Research Networking Center on Neurodegenerative Diseases, University of Castilla-La Mancha
Topics & keywords
- Endocytosis
- Nanoparticle
- Nanotechnology
- Materials science
- Cell
- Biophysics
- Chemistry
- Biochemistry