reviewCellsApr 26, 2020GOLD OA

Structure and Function of Human Matrix Metalloproteinases

HLHelena LaronhaJCJorge Caldeira

Escola Superior de Saúde Egas Moniz · Universidade Nova de Lisboa

PubMed
Indexed incrossrefdoajpubmed

Abstract

The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.

Citation impact

577
total citations
FWCI
22.32
Percentile
100%
References
36
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Matrix metalloproteinase
  • Extracellular matrix
  • Cell biology
  • Function (biology)
  • Matrix (chemical analysis)
  • Chemistry
  • Enzyme
  • Biochemistry
No related works found for this paper.

Funding