The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis

•HDV infection is common among HBsAg-positive people worldwide.•Among HBsAg-positive people, estimated HDV prevalence is 4.5% (95% CI 3.6–5.7).•HDV prevalence in HBsAg-positive hepatology clinic attendees is 16.4% (14.6–18.6).•HDV prevalence is higher in people who inject drugs and who have HCV or HIV.•HDV causes an estimated 18% of cirrhosis and 20% of HCC associated with hepatitis B. Background and AimsThere are uncertainties about the epidemic patterns of HDV infection and its contribution to the burden of liver disease. We estimated the global prevalence of HDV infection and explored its contribution to the development of cirrhosis and hepatocellular carcinoma (HCC) among HBsAg-positive people.MethodsWe…

• WH
  World Health Organization
• WT
  Wellcome Trust

  Award: 109130/Z/15/Z