Contribution of Organofluorine Compounds to Pharmaceuticals
Sagami Chemical Research Institute · Nagoya Institute of Technology · +1 more institution
Abstract
Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in the 1980s, fluorine-containing pharmaceuticals, which are also known as fluoro-pharmaceuticals, have been attracting attention for more than half of a century. Presently, about 20% of the commercial pharmaceuticals are fluoro-pharmaceuticals. In this mini-review, we analyze the prevalence of fluoro-pharmaceuticals in the market and categorize them into several groups based on the chemotype of the fluoro-functional groups, their therapeutic purpose, and the presence of heterocycles and/or chirality to highlight the structural motifs, patterns, and promising trends in fluorine-based drug design. Our database contains 340…
Citation impact
- FWCI
- 77.70
- Percentile
- 100%
- References
- 37
Authors
3Topics & keywords
- Drug
- Chemistry
- Combinatorial chemistry
- Pharmacology
- Medicine