reviewCold Spring Harbor Perspectives in MedicineApr 27, 2020BRONZE OA

Multivariable Mendelian Randomization and Mediation

ESEleanor Sanderson

University of Bristol

PubMed
Indexed incrossrefpubmed

Abstract

Mendelian randomization (MR) is the use of genetic variants associated with an exposure to estimate the causal effect of that exposure on an outcome. Mediation analysis is the method of decomposing the effects of an exposure on an outcome, which act directly, and those that act via mediating variables. These effects are decomposed through the use of multivariable analysis to estimate the causal effects between three types of variables: exposures, mediators, and an outcome. Multivariable MR (MVMR) is a recent extension to MR that uses genetic variants associated with multiple, potentially related exposures to estimate the effect of each exposure on a single outcome. MVMR allows for equivalent analysis to…

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Topics & keywords

Topics
Keywords
  • Mendelian randomization
  • Mediation
  • Multivariable calculus
  • Confounding
  • Causal inference
  • Outcome (game theory)
  • Inference
  • Econometrics
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