reviewTranslational OncologyApr 22, 2020GOLD OA

Epithelial-Mesenchymal Transition in Cancer: A Historical Overview

DRDoménico RibattiRTRoberto TammaTATiziana Annese

University of Bari Aldo Moro

PubMed
Indexed incrossrefdoajpubmed

Abstract

Epithelial-mesenchymal transitions (EMTs), the acquisition of mesenchymal features from epithelial cells, occur during some biological processes and are classified into three types: the first type occurs during embryonic development, the second type is associated with adult tissue regeneration, and the third type occurs in cancer progression. EMT occurring during embryonic development in gastrulation, renal development, and the origin and fate of the neural crest is a highly regulated process, while EMT occurring during tumor progression is highly deregulated. EMT allows the solid tumors to become more malignant, increasing their invasiveness and metastatic activity. Secondary tumors frequently maintain the…

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1,023
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45.16
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100%
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Authors

3

Topics & keywords

Topics
Keywords
  • Epithelial–mesenchymal transition
  • Mesenchymal stem cell
  • Cancer research
  • Neural crest
  • Metastasis
  • Gastrulation
  • Biology
  • Embryonic stem cell
UN Sustainable Development Goals
  • Good health and well-being
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