Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

Epigenetics is dynamic and heritable modifications to the genome that occur independently of DNA sequence. It requires interactions cohesively with various enzymes and other molecular components. Aberrant epigenetic alterations can lead to inappropriate onset of genetic expressions and promote tumorigenesis. As the epigenetic modifiers are susceptible to extrinsic factors and reversible, they are becoming promising targets in multiple cancer therapies. Recently, various epi-drugs have been developed and implicated in clinical use. The use of epi-drugs alone, or in combination with chemotherapy or immunotherapy, has shown compelling outcomes, including augmentation of anti-tumoral effects, overcoming drug…

• RG
  Research Grants Council, University Grants Committee

  Awards: 740608, 17152116, 766211, 17121419
• UO
  University of Hong Kong

  Awards: 200006276, 104004460, 204610519, 202007002, 104004092, 200007008
• HA
  Health and Medical Research Fund

  Awards: 16172751, 200007008, 15162961, 15162961 and 16172751