reviewFrontiers in NeuroscienceApr 21, 2020GOLD OA

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

XSXiaohua SongDLDingxin Long

University of South China

PubMed
Indexed incrossrefdoajpubmed

Abstract

Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which is inhibited by iron chelators and lipophilic antioxidants. In addition to classical regulatory mechanisms, new regulatory factors for ferroptosis have been discovered in recent years, such as the P53 pathway, the activating transcription factor (ATF)3/4 pathway, Beclin 1 (BECN1) pathway, and some non-coding RNA. Ferroptosis is closely related to cancer treatment, neurodegenerative diseases, ischemia-reperfusion of organ, neurotoxicity, and others, in particular, in the field of neurodegenerative diseases treatment has aroused…

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563
total citations
FWCI
38.69
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100%
References
182
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Authors

2

Topics & keywords

Topics
Keywords
  • Neuroscience
  • Amyotrophic lateral sclerosis
  • Medicine
  • Biology
  • Disease
  • Pathology
UN Sustainable Development Goals
  • Good health and well-being
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