articleAmerican Journal of Respiratory and Critical Care MedicineApr 29, 2020HYBRID OA

Respiratory Pathophysiology of Mechanically Ventilated Patients with COVID-19: A Cohort Study

DRDavid R. ZiehrJAJehan AlladinaCRCamille R. PetriJHJason H. MaleyAMAri Moskowitz

Beth Israel Deaconess Medical Center · Massachusetts General Hospital

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Abstract

To the Editor:Five to twenty percent of hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are admitted to the ICU, with mortality reported between 26% and 61.5% (1-3).Nearly all ICU patients present with respiratory failure, and up to 88% are managed with invasive mechanical ventilation (1-3).Descriptions of the pathophysiological characteristics of coronavirus disease (COVID-19) respiratory failure are limited.Reports of preserved respiratory system mechanics despite severe hypoxemia in early small series have led some investigators to hypothesize that a significant proportion of COVID-19 respiratory failure is not the typical acute respiratory distress syndrome…

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Topics & keywords

Topics
Keywords
  • Medicine
  • Coronavirus disease 2019 (COVID-19)
  • Pathophysiology
  • Mechanical ventilation
  • 2019-20 coronavirus outbreak
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Respiratory system
  • Intensive care medicine
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