Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

Doxorubicin (DOX), a chemotherapeutic agent, induces a cardiotoxicity referred to as doxorubicin-induced cardiomyopathy (DIC). This cardiotoxicity often limits chemotherapy for malignancies and is associated with poor prognosis. However, the molecular mechanism underlying this cardiotoxicity is yet to be fully elucidated. Here, we show that DOX downregulated glutathione peroxidase 4 (GPx4) and induced excessive lipid peroxidation through DOX-Fe2+ complex in mitochondria, leading to mitochondria-dependent ferroptosis; we also show that mitochondria-dependent ferroptosis is a major cause of DOX cardiotoxicity. In DIC mice, the left ventricular ejection fraction was significantly impaired, and fibrosis and TUNEL+…

• YF
  YOKOYAMA Foundation for Clinical Pharmacology

  Award: YRY-1911
• TS
  Takeda Science Foundation
• JF
  Japan Foundation for Applied Enzymology
• UM
  Uehara Memorial Foundation
• JA
  Japan Agency for Medical Research and Development

  Awards: JP19gm0910013, JP19ek0109339h0002
• JS
  Japan Society for the Promotion of Science

  Award: 16H07049,18K15892,17K09582,17H03977,18K19405,15H04815,19H03655