reviewNutrientsMay 3, 2020GOLD OA

Obesity, Bioactive Lipids, and Adipose Tissue Inflammation in Insulin Resistance

IKIwona KojtaMCMarta ChacińskaABAgnieszka Błachnio‐Zabielska

Medical University of Białystok

PubMed
Indexed incrossrefdoajpubmed

Abstract

Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes. The exact mechanism by which adipose tissue induces insulin resistance is still unclear. It has been demonstrated that obesity is associated with the adipocyte dysfunction, macrophage infiltration, and low-grade inflammation, which probably contributes to the induction of insulin resistance. Adipose tissue synthesizes and secretes numerous bioactive molecules, namely adipokines and cytokines, which affect the metabolism of both lipids and glucose. Disorders in the synthesis of adipokines and cytokines that occur in obesity lead to changes in lipid and carbohydrates metabolism and, as a consequence, may lead to insulin…

Citation impact

503
total citations
FWCI
33.56
Percentile
100%
References
146
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Insulin resistance
  • Adipokine
  • Adipose tissue
  • Endocrinology
  • Internal medicine
  • Proinflammatory cytokine
  • Lipid metabolism
  • Adipocyte
UN Sustainable Development Goals
  • Good health and well-being
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