Immune cell profiling of COVID-19 patients in the recovery stageby single-cell sequencing

Wen, Wen; Su, Wenru; Tang, Hao; Le, Wenqing; Zhang, Xiaopeng; Zheng, Yingfeng; Liu, Xiuxing; Xie, Lihui; Li, Jianmin; Ye, Jinguo; Dong, Liwei; Cui, Xiuliang; Miao, Yushan; Wang, Depeng; Dong, Jiantao; Xiao, Chuan‐Le; Chen, Wei; Wang, Hongyang

doi:10.1038/s41421-020-0168-9

articleCell DiscoveryMay 4, 2020GOLD OA

Immune cell profiling of COVID-19 patients in the recovery stageby single-cell sequencing

WWWen Wen WSWenru Su HTHao Tang WLWenqing Le XZXiaopeng Zhang

Second Military Medical University · Sun Yat-sen University · +7 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Abstract COVID-19, caused by SARS-CoV-2, has recently affected over 1,200,000 people and killed more than 60,000. The key immune cell subsets change and their states during the course of COVID-19 remain unclear. We sought to comprehensively characterize the transcriptional changes in peripheral blood mononuclear cells during the recovery stage of COVID-19 by single-cell RNA sequencing technique. It was found that T cells decreased remarkably, whereas monocytes increased in patients in the early recovery stage (ERS) of COVID-19. There was an increased ratio of classical CD14 ++ monocytes with high inflammatory gene expression as well as a greater abundance of CD14 ++ IL1β + monocytes in the ERS. CD4 + T cells…

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Topics & keywords

Topics

Keywords

Coronavirus disease 2019 (COVID-19)
Immune system
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Profiling (computer programming)
Single cell sequencing
Cell
2019-20 coronavirus outbreak
Single-cell analysis

UN Sustainable Development Goals

Good health and well-being

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