reviewAutoimmunity ReviewsMay 4, 2020HYBRID OA

Convalescent plasma in Covid-19: Possible mechanisms of action

MRManuel RojasYRYhojan RodríguezDMDiana M. MonsalveYAYeny Acosta‐AmpudiaBCBernardo Camacho

Universidad del Rosario · Universidad Autónoma de Occidente · +5 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible of the coronavirus disease 2019 (COVID-19) pandemic. Therapeutic options including antimalarials, antivirals, and vaccines are under study. Meanwhile the current pandemic has called attention over old therapeutic tools to treat infectious diseases. Convalescent plasma (CP) constitutes the first option in the current situation, since it has been successfully used in other coronaviruses outbreaks. Herein, we discuss the possible mechanisms of action of CP and their repercussion in COVID-19 pathogenesis, including direct neutralization of the virus, control of an overactive immune system (i.e., cytokine storm, Th1/Th17 ratio, complement…

Citation impact

513
total citations
FWCI
12.40
Percentile
100%
References
127
Citations per year

Authors

13

Topics & keywords

Topics
Keywords
  • Cytokine storm
  • Convalescent plasma
  • Medicine
  • Pandemic
  • Coronavirus disease 2019 (COVID-19)
  • Coronavirus
  • Immunology
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
UN Sustainable Development Goals
  • Good health and well-being
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