A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Gordon, David E.; Jang, Gwendolyn Μ.; Bouhaddou, Mehdi; Xu, Jiewei; Obernier, Kirsten; White, Kris M.; O’Meara, Matthew J.; Rezelj, Veronica V.; Guo, Jeffrey; Swaney, Danielle L.; Tummino, Tia A.; Hüttenhain, Ruth; Kaake, Robyn M.; Richards, Alicia; Tutuncuoglu, Beril; Foussard, Helene; Batra, Jyoti; Haas, Kelsey M.; Modak, Maya; Kim, Minkyu; Haas, Paige; Polacco, Benjamin J.; Braberg, Hannes; Fabius, Jacqueline M.; Eckhardt, Manon; Soucheray, Margaret; Bennett, Melanie J.; Çakır, Merve; McGregor, Michael; Li, Qiongyu; Meyer, Bjoern; Roesch, Ferdinand; Vallet, Thomas; Kain, Alice Mac; Miorin, Lisa; Moreno, Elena; Naing, Zun Zar Chi; Zhou, Yuan; Peng, Shiming; Shi, Ying; Zhang, Ziyang; Shen, Wenqi; Kirby, Ilsa T.; Melnyk, James E.; Chorba, John S.; Lou, Kevin; Dai, Shizhong; Barrio‐Hernandez, Inigo; Memon, Danish; Hernández-Armenta, Claudia; Lyu, Jiankun; Mathy, Christopher J.P.; Perica, Tina; Pilla, Kala Bharath; Ganesan, Sai J.; Saltzberg, Daniel J.; Rakesh, Ramachandran; Xi, Liu; Rosenthal, Sara B.; Calviello, Lorenzo; Venkataramanan, Srivats; Liboy-Lugo, José; Lin, Yizhu; Huang, Xi‐Ping; Liu, Yongfeng; Wankowicz, Stephanie A.; Bohn, Markus‐Frederik; Safari, Maliheh; Ugur, Fatima S.; Koh, Cassandra; Savar, Nastaran Sadat; Tran, Quang; Shengjuler, Djoshkun; Fletcher, Sabrina Johanna; O’Neal, Michael C.; Cai, Yiming; Chang, Jason C.; Broadhurst, David; Klippsten, Saker; Sharp, Phillip P.; Wenzell, Nicole A.; Kuzuoğlu‐Öztürk, Duygu; Wang, Hao‐Yuan; Trenker, Raphael; Young, Janet M.; Cavero, Devin A.; Hiatt, Joseph; Roth, Theodore L.; Rathore, Ujjwal; Subramanian, Advait; Noack, Julia; Hubert, Mathieu; Stroud, Robert M.; Frankel, Alan D.; Rosenberg, Oren S.; Verba, Kliment A.; Agard, David A.; Ott, Mélanie; Emerman, Michael; Jura, Natalia; Zastrow, Mark von; Verdin, Eric; Ashworth, Alan; Schwartz, Olivier; d’Enfert, Christophe; Mukherjee, Shaeri; Jacobson, Matthew P.; Malik, Harmit S.; Fujimori, Danica Galonić; Ideker, Trey; Craik, Charles S.; Floor, Stephen N.; Fraser, James S.; Gross, John D.; Šali, Andrej; Roth, Bryan L.; Ruggero, Davide; Taunton, Jack; Kortemme, Tanja; Beltrão, Pedro; Vignuzzi, Marco; García‐Sastre, Adolfo; Shokat, Kevan M.; Shoichet, Brian K.; Krogan, Nevan J.

doi:10.1038/s41586-020-2286-9

articleNatureApr 30, 2020BRONZE OA

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DEDavid E. Gordon GΜGwendolyn Μ. Jang MBMehdi Bouhaddou JXJiewei Xu KOKirsten Obernier

Gladstone Institutes · University of California, San Francisco · +20 more institutions

PubMed

Indexed incrossrefdatacitepubmed

Abstract

No abstract available for this paper.

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4,851

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Authors

125

DE
David E. GordonCorresponding
Gladstone Institutes, University of California, San Francisco, Quantitative BioSciences
GΜ
Gwendolyn Μ. Jang
Gladstone Institutes, University of California, San Francisco, Quantitative BioSciences
MB
Mehdi Bouhaddou
Gladstone Institutes, University of California, San Francisco, Quantitative BioSciences
JX
Jiewei Xu
Gladstone Institutes, University of California, San Francisco, Quantitative BioSciences
KO
Kirsten Obernier
Gladstone Institutes, University of California, San Francisco, Quantitative BioSciences

Topics & keywords

Topics

Keywords

Drug repositioning
Coronavirus
Druggability
Repurposing
Virology
Drug
Drug discovery
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

UN Sustainable Development Goals

Good health and well-being

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