Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein
Brigham and Women's Hospital · St. Luke's Episcopal Hospital · +11 more institutions
Abstract
Previous studies have shown that statin therapy reduces high-sensitivity C-reactive protein levels as well as cholesterol, but no prospective trials have directly addressed the issue of whether elevated levels of high-sensitivity C-reactive protein are beneficial for apparently healthy persons with levels of LDL cholesterol below current thresholds for treatment. This randomized, double-blind, placebo-controlled, multicenter trial study was part of the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) Study. The present study evaluated the effects of rosuvastatin, 20 mg daily, or placebo in 17,802 apparently healthy men and women with LDL cholesterol…
Citation impact
- FWCI
- 425.91
- Percentile
- 100%
- References
- 0
Authors
14- PMPaul M. RidkerCorresponding
Brigham and Women's Hospital, St. Luke's Episcopal Hospital, Universität Ulm, Cornell University, McGill University Health Centre, Herlev Hospital, Copenhagen University Hospital, Amsterdam UMC Location University of Amsterdam, Weatherford College, Servicio Diabetología Hospital Córdoba, University of Glasgow, Universidade Federal de São Paulo, University of Amsterdam
- EDEleanor Danielson
Brigham and Women's Hospital, St. Luke's Episcopal Hospital, Universität Ulm, Cornell University, McGill University Health Centre, Herlev Hospital, Copenhagen University Hospital, Amsterdam UMC Location University of Amsterdam, Weatherford College, Servicio Diabetología Hospital Córdoba, University of Glasgow, Universidade Federal de São Paulo, University of Amsterdam
- FAFrancisco Antônio Helfenstein Fonseca
Brigham and Women's Hospital, St. Luke's Episcopal Hospital, Universität Ulm, Cornell University, McGill University Health Centre, Herlev Hospital, Copenhagen University Hospital, Amsterdam UMC Location University of Amsterdam, Weatherford College, Servicio Diabetología Hospital Córdoba, University of Glasgow, Universidade Federal de São Paulo, University of Amsterdam
- JGJacques Genest
Brigham and Women's Hospital, St. Luke's Episcopal Hospital, Universität Ulm, Cornell University, McGill University Health Centre, Herlev Hospital, Copenhagen University Hospital, Amsterdam UMC Location University of Amsterdam, Weatherford College, Servicio Diabetología Hospital Córdoba, University of Glasgow, Universidade Federal de São Paulo, University of Amsterdam
- AMAntonio M. Gotto
Brigham and Women's Hospital, St. Luke's Episcopal Hospital, Universität Ulm, Cornell University, McGill University Health Centre, Herlev Hospital, Copenhagen University Hospital, Amsterdam UMC Location University of Amsterdam, Weatherford College, Servicio Diabetología Hospital Córdoba, University of Glasgow, Universidade Federal de São Paulo, University of Amsterdam
Topics & keywords
- Rosuvastatin
- Medicine
- Placebo
- Hazard ratio
- C-reactive protein
- Rosuvastatin Calcium
- Internal medicine
- Confidence interval
- Good health and well-being