Immune responses to stroke: mechanisms, modulation, and therapeutic potential

Stroke is the second leading cause of death worldwide and a leading cause of disability. Most strokes are caused by occlusion of a major cerebral artery, and substantial advances have been made in elucidating how ischemia damages the brain. In particular, increasing evidence points to a double-edged role of the immune system in stroke pathophysiology. In the acute phase, innate immune cells invade brain and meninges and contribute to ischemic damage, but may also be protective. At the same time, danger signals released into the circulation by damaged brain cells lead to activation of systemic immunity, followed by profound immunodepression that promotes life-threatening infections. In the chronic phase,…

• AH
  American Heart Association

  Award: 19PABHI34580007
• NI
  National Institutes of Health

  Awards: NS081179, NS34179, R01-NS34179
• CO
  College of Veterinary Medicine, Cornell University