The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies
La Ligue Contre le Cancer · Inserm · +3 more institutions
Abstract
Tumor cells constantly interact with their microenvironment, which comprises a variety of immune cells together with endothelial cells and fibroblasts. The composition of the tumor microenvironment (TME) has been shown to influence response to immune checkpoint blockade (ICB). ICB takes advantage of immune cell infiltration in the tumor to reinvigorate an efficacious antitumoral immune response. In addition to tumor cell intrinsic biomarkers, increasing data pinpoint the importance of the TME in guiding patient selection and combination therapies. Here, we review recent efforts in determining how various components of the TME can influence response and resistance to ICB. Although a large body of evidence…
Citation impact
- FWCI
- 33.83
- Percentile
- 100%
- References
- 146
Authors
5- FPFlorent PetitprezCorresponding
La Ligue Contre le Cancer
- MMMaxime Meylan
Inserm, La Ligue Contre le Cancer, Université Paris Cité, Sorbonne Université, Centre de Recherche des Cordeliers
- ADAurélien de Reyniès
La Ligue Contre le Cancer
- CSCatherine Sautès‐Fridman
Université Paris Cité, Inserm, Sorbonne Université, Centre de Recherche des Cordeliers
- WHWolf H. FridmanCorresponding
Centre de Recherche des Cordeliers, Inserm, Université Paris Cité, Sorbonne Université
Topics & keywords
- Tumor microenvironment
- Immune checkpoint
- Immune system
- Cancer research
- Immunotherapy
- Medicine
- Immunology
- Biology
- Good health and well-being