A human monoclonal antibody blocking SARS-CoV-2 infection

Wang, Chunyan; Li, Wentao; Drabek, Dubravka; Okba, Nisreen M.A.; Haperen, Rien van; Osterhaus, Albert D. M. E.; Kuppeveld, Frank J. M. van; Haagmans, Bart L.; Grosveld, Frank; Bosch, Berend‐Jan

doi:10.1038/s41467-020-16256-y

articleNature CommunicationsMay 4, 2020GOLD OA

A human monoclonal antibody blocking SARS-CoV-2 infection

CWChunyan Wang WLWentao Li DDDubravka Drabek NMNisreen M.A. Okba RVRien van Haperen

Utrecht University · Erasmus MC · +2 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

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1,153

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References: 32

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Authors

10

Topics & keywords

Topics

Keywords

Monoclonal antibody
Virology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Coronavirus disease 2019 (COVID-19)
Epitope
Antibody
2019-20 coronavirus outbreak
Coronavirus

UN Sustainable Development Goals

Good health and well-being

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