Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)
General Hospital of Central Theater Command · Central Hospital of Wuhan · +2 more institutions
Abstract
BACKGROUND The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear. METHODS We retrospectively reviewed the counts of T cells and serum cytokine concentration from data of 522 patients with laboratory-confirmed COVID-19 and 40 healthy controls. In addition, the expression of T cell exhaustion markers were measured in 14 COVID-19 cases. RESULTS The number of total T cells, CD4+ and CD8+ T cells were dramatically reduced in COVID-19 patients, especially in patients requiring…
Citation impact
- FWCI
- 55.65
- Percentile
- 100%
- References
- 42
Authors
15- BDBo Diao
General Hospital of Central Theater Command, Central Hospital of Wuhan
- CWChenhui Wang
Army Medical University
- YTYingjun Tan
General Hospital of Central Theater Command, Central Hospital of Wuhan
- XCXiewan Chen
Army Medical University
- YLYing Liu
General Hospital of Central Theater Command, Central Hospital of Wuhan
Topics & keywords
- Medicine
- CD8
- Intensive care unit
- Coronavirus disease 2019 (COVID-19)
- T cell
- Immunology
- Cytotoxic T cell
- Coronavirus
- Good health and well-being