Angiotensin‐converting enzyme 2 ( ACE2 ), SARS‐CoV ‐2 and the pathophysiology of coronavirus disease 2019 ( COVID ‐19)
University Medical Center Groningen · University of Groningen · +1 more institution
Abstract
Angiotensin-converting enzyme 2 (ACE2) has been established as the functional host receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the current devastating worldwide pandemic of coronavirus disease 2019 (COVID-19). ACE2 is abundantly expressed in a variety of cells residing in many different human organs. In human physiology, ACE2 is a pivotal counter-regulatory enzyme to ACE by the breakdown of angiotensin II, the central player in the renin-angiotensin-aldosterone system (RAAS) and the main substrate of ACE2. Many factors have been associated with both altered ACE2 expression and COVID-19 severity and progression, including age, sex, ethnicity, medication,…
Citation impact
- FWCI
- 22.39
- Percentile
- 100%
- References
- 236
Authors
13- ARArno R. Bourgonje
University Medical Center Groningen, University of Groningen
- AEAmaal Eman Abdulle
University Medical Center Groningen, University of Groningen
- WTWim Timens
University Medical Center Groningen, University of Groningen
- JHJan‐Luuk Hillebrands
University Medical Center Groningen, University of Groningen
- GNGerjan Navis
University Medical Center Groningen, University of Groningen
Topics & keywords
- Angiotensin-converting enzyme 2
- Pathophysiology
- Disease
- Coronavirus
- Pathogenesis
- Immunology
- Medicine
- Renin–angiotensin system
- Good health and well-being