The Brain’s Glymphatic System: Current Controversies
University of Rochester Medical Center · University of Copenhagen
Abstract
Several global models of brain fluid transport have been proposed. When assessing these models, it is imperative that they are based on observations in live animals. Cerebrospinal fluid (CSF) tracer distribution in histological sections mostly reflects nonphysiological events triggered after death.The literature suggests that diffusion and convective flow both contribute to clearance of CNS solutes. Experiments that are aimed at defining the relative contribution of diffusion versus convection are difficult to interpret because minor changes in physiological variables, such as body posture or respiratory rate, can significantly affect both pathways. Invasive procedures, such as tracer injection, will primarily…
Citation impact
- FWCI
- 33.33
- Percentile
- 100%
- References
- 73
Authors
3Topics & keywords
- Glymphatic system
- Neuroscience
- Current (fluid)
- Psychology
- Cognitive science
- Medicine
- Cerebrospinal fluid
- Physics
- Clean water and sanitation
Funding
- GOGovernment of South Australia
- FLFondation Leducq
- LLundbeckfonden
- NNNovo Nordisk
- HLH. Lundbeck A/S
- NINational Institutes of HealthAwards: RF1AG057575, W911NF1910280, R01NS100366
- MUMultidisciplinary University Research InitiativeAward: W911NF1910280
- H2Horizon 2020Award: 666881
- NINational Institute on AgingAwards: R01NS100366, RF1AG057575
- NINational Institute of Neurological Disorders and Stroke
- ARArmy Research OfficeAwards: MURI W911NF1910280, W911NF1910280