Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease
Center for Children · Laboratory of Molecular Genetics · +9 more institutions
Abstract
We report the implantation of patient-derived midbrain dopaminergic progenitor cells, differentiated in vitro from autologous induced pluripotent stem cells (iPSCs), in a patient with idiopathic Parkinson's disease. The patient-specific progenitor cells were produced under Good Manufacturing Practice conditions and characterized as having the phenotypic properties of substantia nigra pars compacta neurons; testing in a humanized mouse model (involving peripheral-blood mononuclear cells) indicated an absence of immunogenicity to these cells. The cells were implanted into the putamen (left hemisphere followed by right hemisphere, 6 months apart) of a patient with Parkinson's disease, without the need for…
Citation impact
- FWCI
- 26.02
- Percentile
- 100%
- References
- 35
Authors
25- JSJeffrey S. SchweitzerCorresponding
Center for Children
- BSBin Song
Laboratory of Molecular Genetics, Center for Children
- TMTodd M. Herrington
Center for Children, Neurology, Inc
- TYTae Yoon Park
Laboratory of Molecular Genetics, Center for Children
- NLNayeon Lee
Laboratory of Molecular Genetics, Center for Children
Topics & keywords
- Substantia nigra
- Pars compacta
- Induced pluripotent stem cell
- Progenitor cell
- Dopaminergic
- Medicine
- Parkinson's disease
- Neuroscience