Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
Fudan University · State Key Laboratory of Medical Neurobiology
Abstract
Neovascularization and vascular remodeling are functionally important for brain repair after stroke. We show that neutrophils accumulate in the peri-infarct cortex during all stages of ischemic stroke. Neutrophils producing intravascular and intraparenchymal neutrophil extracellular traps (NETs) peak at 3-5 days. Neutrophil depletion reduces blood-brain barrier (BBB) breakdown and enhances neovascularization at 14 days. Peptidylarginine deiminase 4 (PAD4), an enzyme essential for NET formation, is upregulated in peri-ischemic brains. Overexpression of PAD4 induces an increase in NET formation that is accompanied by reduced neovascularization and increased BBB damage. Disruption of NETs by DNase 1 and…
Citation impact
- FWCI
- 19.00
- Percentile
- 100%
- References
- 63
Authors
14- LKLijing KangCorresponding
Fudan University, State Key Laboratory of Medical Neurobiology
- HYHuilin Yu
Fudan University, State Key Laboratory of Medical Neurobiology
- XYXing Yang
Fudan University, State Key Laboratory of Medical Neurobiology
- YZYuanbo Zhu
Fudan University, State Key Laboratory of Medical Neurobiology
- XBXiaofei Bai
Fudan University, State Key Laboratory of Medical Neurobiology
Topics & keywords
- Neutrophil extracellular traps
- Extracellular
- Stroke (engine)
- Inflammation
- Medicine
- Chemistry
- Cell biology
- Immunology
- Good health and well-being