SARS-CoV-2 infection protects against rechallenge in rhesus macaques

Immunity from reinfection One of the many open questions about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is whether an individual who has cleared the virus can be infected a second time and get sick. Chandrashekar et al. and Deng et al. generated rhesus macaque models of SARS-CoV-2 infection and tested whether natural SARS-CoV-2 infection could result in immunity to viral rechallenge. They found that animals indeed developed immune responses that protected against a second infection. Although there are differences between SARS-CoV-2 infection in macaques and in humans, these findings have key implications for public health and economic initiatives if validated in human studies.…

• BW
  Burroughs Wellcome Fund
• BA
  Bill and Melinda Gates Foundation

  Award: INV-006131
• BI
  Beth Israel Deaconess Medical Center
• RI
  Ragon Institute of MGH, MIT and Harvard
• MC
  Massachusetts Consortium on Pathogen Readiness
• NI
  National Institutes of Health

  Awards: OD011092, OD025002, AI007151, 272201700036I-0-759301900131-1, AI100625, AI110700, AI132178, AI149644, AI108197, AI135098, CA225088, OD024917, AI129797, AI124377, AI128751, AI126603, AI146779, AI007387
• JR
  Janssen Research and Development