Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles
University of Maryland, Baltimore · Jordan University of Science and Technology · +2 more institutions
Abstract
The current outbreak of the pandemic coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) demands its rapid, convenient, and large-scale diagnosis to downregulate its spread within as well as across the communities. But the reliability, reproducibility, and selectivity of majority of such diagnostic tests fail when they are tested either to a viral load at its early representation or to a viral gene mutated during its current spread. In this regard, a selective "naked-eye" detection of SARS-CoV-2 is highly desirable, which can be tested without accessing any advanced instrumental techniques. We herein report the development of a colorimetric assay based…
Citation impact
- FWCI
- 15.75
- Percentile
- 100%
- References
- 57
Authors
5- PMParikshit Moitra
University of Maryland, Baltimore
- MAMaha Alafeef
University of Maryland, Baltimore, Jordan University of Science and Technology, University of Illinois Urbana-Champaign
- KDKetan Dighe
University of Maryland, Baltimore County
- MBMatthew B. Frieman
University of Maryland, Baltimore
- DPDipanjan PanCorresponding
University of Maryland, Baltimore, University of Illinois Urbana-Champaign, University of Maryland, Baltimore County
Topics & keywords
- Oligonucleotide
- Naked eye
- Nanoparticle
- Plasmon
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Gene
- Molecular biology
- Nanotechnology
- Good health and well-being