articleScienceMay 21, 2020GREEN OA

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

GDGabriela Desdín-MicóGSGonzalo Soto‐HerederoJAJuan ArandaJOJorge OllerECElisa Carrasco

Consejo Superior de Investigaciones Científicas · Research Institute Hospital 12 de Octubre · +13 more institutions

PubMed
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Abstract

Inflammaging? Blame T cells! Mitochondrial dysfunction in various tissues is a prominent characteristic of age-related deterioration, but it is unclear how mitochondrial dysfunction in particular cell types contributes to this process. Desdín-Micó et al. generated mice with T cells that were specifically deficient in a mitochondrial DNA–stabilizing protein. These animals exhibited multiple features associated with aging, including neurological, metabolic, muscular, and cardiovascular impairments. The defective T cells initiated an inflammatory program similar to that observed in older animals, a process called “inflammaging.” Blocking the cytokine tumor necrosis factor–α or administering precursors of the…

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Topics & keywords

Topics
Keywords
  • Senescence
  • Mitochondrion
  • Cytokine
  • Tumor necrosis factor alpha
  • Mitochondrial DNA
  • Biology
  • Medicine
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
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