Interaction between microbiota and immunity in health and disease
Sun Yat-sen University · The First Affiliated Hospital, Sun Yat-sen University · +6 more institutions
Abstract
The interplay between the commensal microbiota and the mammalian immune system development and function includes multifold interactions in homeostasis and disease. The microbiome plays critical roles in the training and development of major components of the host's innate and adaptive immune system, while the immune system orchestrates the maintenance of key features of host-microbe symbiosis. In a genetically susceptible host, imbalances in microbiota-immunity interactions under defined environmental contexts are believed to contribute to the pathogenesis of a multitude of immune-mediated disorders. Here, we review features of microbiome-immunity crosstalk and their roles in health and disease, while…
Citation impact
- FWCI
- 147.12
- Percentile
- 100%
- References
- 277
Authors
3- DZDanping ZhengCorresponding
Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University, Weizmann Institute of Science
- TLTimur Liwinski
Universität Hamburg, University Medical Center Hamburg-Eppendorf, Weizmann Institute of Science
- EEEran Elinav
German Cancer Research Center, Heidelberg University, DKFZ-ZMBH Alliance, Weizmann Institute of Science
Topics & keywords
- Microbiome
- Immune system
- Biology
- Disease
- Crosstalk
- Immunity
- Innate immune system
- Acquired immune system