Reactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field

The unique physicochemical characteristics of nanoparticles have recently gained increasing attention in a diverse set of applications, particularly in the biomedical field. However, concerns about the potential toxicological effects of nanoparticles remain, as they have a higher tendency to generate excessive amounts of reactive oxygen species (ROS). Due to the strong oxidation potential, the excess ROS induced by nanoparticles can result in the damage of biomolecules and organelle structures and lead to protein oxidative carbonylation, lipid peroxidation, DNA/RNA breakage, and membrane structure destruction, which further cause necrosis, apoptosis, or even mutagenesis. This review aims to give a summary of…

• NN
  National Natural Science Foundation of China

  Award: 31900957,31671447,31430041,91849209
• NS
  Natural Science Foundation of Shandong Province

  Award: ZR2019QC007
• PR
  Postdoctoral Research Foundation of China

  Award: 2019M652326