The potential role of RNA N6-methyladenosine in Cancer progression
Nantong University · Affiliated Hospital of Nantong University
Abstract
N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A is installed by m6A methyltransferases (METTL3/14, WTAP, RBM15/15B, VIRMA and ZC3H13, termed "writers"), removed by demethylases (FTO, ALKBH5, and ALKBH3, termed "erasers"), and recognized by m6A-binding proteins (YTHDC1/2, YTHDF1/2/3, IGF2BP1/2/3, HNRNP, and eIF3, termed "readers"). Accumulating evidence suggests that m6A RNA methylation greatly impacts RNA metabolism and is involved in the pathogenesis of many kinds of diseases, including cancers. In this review, we focus on the physiological functions of m6A modification and its related…
Citation impact
- FWCI
- 52.01
- Percentile
- 100%
- References
- 160
Authors
4- TWTianyi WangCorresponding
Nantong University, Affiliated Hospital of Nantong University
- SKShan Kong
Nantong University, Affiliated Hospital of Nantong University
- MTMei Tao
Nantong University, Affiliated Hospital of Nantong University
- SJShaoqing Ju
Nantong University, Affiliated Hospital of Nantong University
Topics & keywords
- N6-Methyladenosine
- Biology
- RNA methylation
- Methyltransferase
- RNA
- Methylation
- Messenger RNA
- RNA-binding protein
- Good health and well-being