Dendritic Cells and Their Role in Immunotherapy

Despite significant advances in the field of cancer immunotherapy, the majority of patients still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have long been a focus of cancer immunotherapy due to their role in inducing protective adaptive immunity, but cancer vaccines have shown limited efficacy in the past. With the advent of immune checkpoint blockade and the ability to identify patient-specific neoantigens, new vaccines, and combinatorial therapies are being evaluated in the clinic. Dendritic cells are also emerging as critical regulators of the immune response within tumors. Understanding how to augment the function of these intratumoral dendritic cells could offer…

• UD
  U.S. Department of Defense

  Awards: W81XWH-20-1-0012, W81XWH
• FD
  Florida Department of Health
• NI
  National Institutes of Health

  Award: W81XWH
• NC
  National Cancer Institute

  Awards: F99CA245807, R01CA230610, F31CA224963