Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

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doi:10.1038/s41467-020-15701-2

articleNature CommunicationsMay 26, 2020GOLD OA

Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

JWJacob W. Vogel YIYasser Iturria‐Medina OSOlof Strandberg RSRuben Smith ELElizabeth Levitis

Montreal Neurological Institute and Hospital · McGill University · +83 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) to simulate tau spread, and compare these simulations to observed patterns measured using tau-PET in 312 individuals along Alzheimer's disease continuum. Up to 70% of the variance in the overall spatial pattern of tau can be explained by our model. Surprisingly, the ESM predicts the spatial patterns of tau irrespective of whether brain Aβ is present, but regions with greater Aβ burden show greater tau than predicted by connectivity patterns, suggesting a role…

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Topics & keywords

Topics

Keywords

Tau pathology
Neuroscience
Tau protein
Alzheimer's disease
Human brain
Disease
Pathological
Biology

UN Sustainable Development Goals

Good health and well-being

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