articleCell SystemsJun 1, 2020HYBRID OA

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

CBChristoph B. MessnerVDVadim DemichevDWDaniel WendischLMLaura MichalickMWMatthew White

The Francis Crick Institute · University of Cambridge · +7 more institutions

PubMed
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Abstract

The COVID-19 pandemic is an unprecedented global challenge, and point-of-care diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput serum and plasma proteomics that builds on ISO13485 standardization to facilitate simple implementation in regulated clinical laboratories. Our low-cost workflow handles up to 180 samples per day, enables high precision quantification, and reduces batch effects for large-scale and longitudinal studies. We use our platform on samples collected from a cohort of early hospitalized cases of the SARS-CoV-2 pandemic and identify 27 potential biomarkers that are differentially expressed depending on the WHO severity grade of COVID-19. They…

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Topics & keywords

Topics
Keywords
  • Coronavirus disease 2019 (COVID-19)
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Throughput
  • Pandemic
  • Proteomics
  • Standardization
  • Workflow
  • Computer science
UN Sustainable Development Goals
  • Good health and well-being
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