Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

Programmed cell death plays crucial roles in organismal development and host defense. Recent studies have highlighted mechanistic overlaps and extensive, multifaceted crosstalk between pyroptosis, apoptosis, and necroptosis, three programmed cell death pathways traditionally considered autonomous. The growing body of evidence, in conjunction with the identification of molecules controlling the concomitant activation of all three pathways by pathological triggers, has led to the development of the concept of PANoptosis. In PANoptosis, pyroptosis, apoptosis, and necroptosis are activated collectively which can circumvent pathogen-mediated inhibition of individual death pathways. Many of the molecular details of…

• AL
  American Lebanese Syrian Associated Charities

  Awards: CA163507, AI124346, AR056296, AI101935
• NI
  National Institutes of Health

  Awards: AR056296, CA163507, AI101935, AI124346