articleCell ResearchMay 28, 2020HYBRID OA

The future of cancer immunotherapy: microenvironment-targeting combinations

YRYonina R. Murciano‐GoroffABAllison Betof WarnerJDJedd D. Wolchok

Memorial Sloan Kettering Cancer Center · Cornell University · +2 more institutions

PubMed
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Abstract

Immunotherapy holds the potential to induce durable responses, but only a minority of patients currently respond. The etiologies of primary and secondary resistance to immunotherapy are multifaceted, deriving not only from tumor intrinsic factors, but also from the complex interplay between cancer and its microenvironment. In addressing frontiers in clinical immunotherapy, we describe two categories of approaches to the design of novel drugs and combination therapies: the first involves direct modification of the tumor, while the second indirectly enhances immunogenicity through alteration of the microenvironment. By systematically addressing the factors that mediate resistance, we are able to identify…

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Topics & keywords

Topics
Keywords
  • Immunotherapy
  • Tumor microenvironment
  • Immunogenicity
  • Cancer immunotherapy
  • Cancer
  • Medicine
  • Cancer research
  • Computational biology
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