The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

Littlejohns, Thomas J.; Holliday, Jo; Gibson, Lorna M; Garratt, Steve; Oesingmann, Niels; Alfaro‐Almagro, Fidel; Bell, Jimmy D.; Boultwood, Chris; Collins, Rory; Conroy, Megan; Crabtree, Nicola; Doherty, Nicola; Frangi, Alejandro F.; Harvey, Nicholas C.; Leeson, Paul; Miller, Karla L.; Neubauer, Stefan; Petersen, Steffen E.; Sellors, Jonathan; Sheard, Simon; Smith, Stephen M.; Sudlow, Cathie; Matthews, Paul M.; Allen, Naomi E.

doi:10.1038/s41467-020-15948-9

reviewNature CommunicationsMay 26, 2020GOLD OA

The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

TJThomas J. Littlejohns JHJo Holliday LMLorna M Gibson SGSteve Garratt NONiels Oesingmann

University of Oxford · Edinburgh Royal Infirmary · +12 more institutions

PubMed

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Abstract

UK Biobank is a population-based cohort of half a million participants aged 40-69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.

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Topics

Keywords

Biobank
Cohort
Magnetic resonance imaging
Medicine
Population
Medical physics
Data science
Computer science

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