Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While the majority of patients were considered mild, critically ill patients involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm is associated with severe outcome. We enrolled 102 COVID-19 patients who were admitted to Renmin Hospital (Wuhan, China). All patients were classified into moderate, severe and critical groups according to their symptoms. 45 control samples of healthy volunteers were also included. Inflammatory cytokines and C-Reactive Protein (CRP) profiles of serum samples were…

• NN
  National Natural Science Foundation of China
• ZU
  Zhejiang University

  Award: 2020XGZX089
• UO
  University of Chinese Academy of Sciences

  Award: 2020HMZD21