Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

Zhang, Min; Yang, Hui; Wan, Lingfei; Wang, Zhao-Hai; Wang, Haiyang; Chen, Ge; Liu, Yunhui; Hao, Yajing; Zhang, Dongdong; Shi, Gaona; Gong, Yandong; Ni, Yanli; Wang, Chaojie; Zhang, Yuan; Xi, Jiafei; Wang, Sen; Shi, Lei; Zhang, Lina; Yue, Wen; Pei, Xuetao; Liu, Bing; Yan, Xinlong

doi:10.1016/j.jhep.2020.05.039

articleJournal of HepatologyJun 5, 2020HYBRID OA

Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

MZMin Zhang HYHui Yang LWLingfei Wan ZWZhao-Hai Wang HWHaiyang Wang

Academy of Military Medical Sciences · Chinese PLA General Hospital · +10 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

•Single cell transcriptomic datasets are a valuable resource to dissect cellular diversity and intercellular crosstalk of human ICCs.•Malignant cells displayed remarkable inter-tumor heterogeneity and Tregs revealed highly immunosuppressive characteristics.•Six distinct fibroblast subsets were defined in ICCs and adjacent tissues.•CD146+ vCAFs, comprising most of the fibroblasts, had tight interactions with malignant cells through IL-6/IL-6R axis.•Tumor exosomal miR-9-5p elicited IL-6 expression in vCAFs, contributing to ICC progression via upregulation of EZH2. Background & AimsIntrahepatic cholangiocarcinoma (ICC) is the second most common liver malignancy. ICC typically features remarkable cellular…

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Topics & keywords

Topics

Keywords

Biology
Stromal cell
Cancer-Associated Fibroblasts
Transcriptome
Cancer research
Tumor microenvironment
Fibroblast
Epigenetics

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