reviewJournal of Medicinal ChemistryJun 8, 2020Closed access

COVID-19: Drug Targets and Potential Treatments

CGCarmen GilTGTiziana GinexIMInés MaestroVNVanesa NozalLBLucía Barrado-Gil

Centro de Investigaciones Biológicas Margarita Salas · Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria · +1 more institution

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Abstract

Currently, humans are immersed in a pandemic caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health worldwide. To date, no drug or vaccine has been approved to treat the severe disease caused by this coronavirus, COVID-19. In this paper, we will focus on the main virus-based and host-based targets that can guide efforts in medicinal chemistry to discover new drugs for this devastating disease. In principle, all CoV enzymes and proteins involved in viral replication and the control of host cellular machineries are potentially druggable targets in the search for therapeutic options for SARS-CoV-2. This Perspective provides an overview of the main…

Citation impact

468
total citations
FWCI
9.71
Percentile
100%
References
256
Citations per year

Authors

11

Topics & keywords

Topics
Keywords
  • Druggability
  • Coronavirus
  • Antiviral drug
  • Drug
  • Pandemic
  • Drug discovery
  • Disease
  • Immune system
UN Sustainable Development Goals
  • Good health and well-being
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