Inflammasome activation and regulation: toward a better understanding of complex mechanisms

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein, inflammatory caspases, and in some but not all cases an adapter protein connecting the two. They can be activated by a repertoire of endogenous and exogenous stimuli, leading to enzymatic activation of canonical caspase-1, noncanonical caspase-11 (or the equivalent caspase-4 and caspase-5 in humans) or caspase-8, resulting in secretion of IL-1β and IL-18, as well as apoptotic and pyroptotic cell death. Appropriate inflammasome activation is vital for the host to cope with foreign pathogens or tissue damage, while aberrant inflammasome activation can cause uncontrolled tissue responses that may contribute to various diseases,…

• HH
  Howard Hughes Medical Institute
• BA
  Bill and Melinda Gates Foundation
• LM
  Leona M. and Harry B. Helmsley Charitable Trust
• CI
  Canadian Institute for Advanced Research
• DF
  Deutsche Forschungsgemeinschaft

  Award: 420943353
• CH
  Clalit Health Services