FastSurfer - A fast and accurate deep learning based neuroimaging pipeline
German Center for Neurodegenerative Diseases · Harvard University · +2 more institutions
Abstract
Traditional neuroimage analysis pipelines involve computationally intensive, time-consuming optimization steps, and thus, do not scale well to large cohort studies with thousands or tens of thousands of individuals. In this work we propose a fast and accurate deep learning based neuroimaging pipeline for the automated processing of structural human brain MRI scans, replicating FreeSurfer's anatomical segmentation including surface reconstruction and cortical parcellation. To this end, we introduce an advanced deep learning architecture capable of whole-brain segmentation into 95 classes. The network architecture incorporates local and global competition via competitive dense blocks and competitive skip…
Citation impact
- FWCI
- 30.30
- Percentile
- 100%
- References
- 163
Authors
6- LHLeonie Henschel
German Center for Neurodegenerative Diseases
- SCSailesh Conjeti
German Center for Neurodegenerative Diseases
- SESantiago Estrada
German Center for Neurodegenerative Diseases
- KDKersten Diers
German Center for Neurodegenerative Diseases
- BFBruce Fischl
Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging
Topics & keywords
- Pipeline (software)
- Computer science
- Deep learning
- Neuroimaging
- Segmentation
- Artificial intelligence
- Generalizability theory
- Pattern recognition (psychology)
Funding
- UDU.S. Department of DefenseAward: W81XWH-12-2-0012
- GGlaxoSmithKline
- UOUniversity of Southern California
- ADAlzheimer's Disease Neuroimaging Initiative
- NCNorthern California Institute for Research and Education
- BFBundesministerium für Bildung und ForschungAward: 031L0206 CompLS2 DeepNI
- FEFujirebio Europe
- HLH. Lundbeck A/S
- ASAlzheimer’s SocietyAward: RF116
- NINational Institutes of HealthAwards: U01 AG024904, R01LM012719, U01MH117023, R01NS083534
- GGenentech
- GHGE Healthcare
- MCMcDonnell Center for Systems Neuroscience
- NINational Institute on AgingAwards: 1R01AG064027, R01AG016495, 5R01AG008122
- NINational Institute of Mental Health
- NINational Institute of Diabetes and Digestive and Kidney DiseasesAward: 1-R21-DK-108277-01
- NINational Institute of Neurological Disorders and StrokeAwards: R01NS070963, R21NS072652, 5U24NS10059103, 5U01NS086625, R01NS0525851, 1S10RR023043, 1S10RR019307, R01NS105820, 1S10RR023401
- NINational Institute of Biomedical Imaging and BioengineeringAwards: P41EB015896, R01EB019956, 1R01EB023281, 1U54MH091657, R21EB018907, R01EB006758
- NBNIH Blueprint for Neuroscience ResearchAward: 5U01-MH093765
- JAJohnson and Johnson Pharmaceutical Research and Development
- JAJanssen Alzheimer Immunotherapy Research And Development