Broad neutralization of SARS-related viruses by human monoclonal antibodies

Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs) are urgently needed. To gain a deeper understanding of cross-neutralizing antibody responses, we mined the memory B cell repertoire of a convalescent severe acute respiratory syndrome (SARS) donor and identified 200 SARS coronavirus 2 (SARS-CoV-2) binding antibodies that target multiple conserved sites on the spike (S) protein. A large proportion of the non-neutralizing antibodies display high levels of somatic hypermutation and cross-react with circulating HCoVs, suggesting recall of preexisting memory B cells elicited by prior HCoV infections. Several antibodies potently cross-neutralize SARS-CoV, SARS-CoV-2, and the bat…

• BA
  Bill and Melinda Gates Foundation

  Award: OPP 1183956
• NI
  National Institutes of Health

  Awards: U19 AI142777, AI127521, R01-AI132633, R01-AI127521, R01AI132317
• NI
  National Institute of Allergy and Infectious Diseases

  Awards: AI142777, R01-AI127521, U19 AI142777, AI127521