Modulation of the Inflammatory Response and Bone Healing

The optimal treatment for complex fractures and large bone defects is an important unsolved issue in orthopedics and related specialties. Approximately 5-10% of fractures fail to heal and develop non-unions. Bone healing can be characterized by three partially overlapping phases: the inflammatory phase, the repair phase, and the remodeling phase. Eventual healing is highly dependent on the initial inflammatory phase, which is affected by both the local and systemic responses to the injurious stimulus. Furthermore, immune cells and mesenchymal stromal cells (MSCs) participate in critical inter-cellular communication or crosstalk to modulate bone healing. Deficiencies in this inter-cellular exchange, inhibition…

• FF
  Foundation for the National Institutes of Health

  Awards: R01AR063717, RO1AR72613, R01AR073145, R01AR055650
• NI
  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Awards: R01AR063717, R01AR073145