Parkinson’s disease: etiopathogenesis and treatment
Baylor College of Medicine · Singapore General Hospital · +1 more institution
Abstract
The concept of 'idiopathic' Parkinson's disease (PD) as a single entity has been challenged with the identification of several clinical subtypes, pathogenic genes and putative causative environmental agents. In addition to classic motor symptoms, non-motor manifestations (such as rapid eye movement sleep disorder, anosmia, constipation and depression) appear at prodromic/premotor stage and evolve, along with cognitive impairment and dysautonomia, as the disease progresses, often dominating the advanced stages of the disease. The key molecular pathogenic mechanisms include α-synuclein misfolding and aggregation, mitochondrial dysfunction, impairment of protein clearance (associated with deficient…
Citation impact
- FWCI
- 42.23
- Percentile
- 100%
- References
- 139
Authors
2Topics & keywords
- Medicine
- Parkinson's disease
- Neuroprotection
- Disease
- Neuroscience
- Natalizumab
- Bioinformatics
- Psychology
- Good health and well-being