articleJCI InsightJun 19, 2020GOLD OA

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

TTTiffany ThomasDSDavide StefanoniJAJulie A. ReiszTNTravis NemkovLBLorenzo Bertolone

Columbia University · University of Colorado Anschutz Medical Campus · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

BACKGROUNDReprogramming of host metabolism supports viral pathogenesis by fueling viral proliferation, by providing, for example, free amino acids and fatty acids as building blocks.METHODSTo investigate metabolic effects of SARS-CoV-2 infection, we evaluated serum metabolites of patients with COVID-19 (n = 33; diagnosed by nucleic acid testing), as compared with COVID-19-negative controls (n = 16).RESULTSTargeted and untargeted metabolomics analyses identified altered tryptophan metabolism into the kynurenine pathway, which regulates inflammation and immunity. Indeed, these changes in tryptophan metabolism correlated with interleukin-6 (IL-6) levels. Widespread dysregulation of nitrogen metabolism was also…

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598
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12

Topics & keywords

Topics
Keywords
  • Coronavirus disease 2019 (COVID-19)
  • Pathogenesis
  • Kynurenine
  • Metabolism
  • Kynurenine pathway
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Fatty acid metabolism
  • Viral infection
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