Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury
Washington University in St. Louis · Kyoto Prefectural University of Medicine
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Abstract
Significance Single nucleus RNA sequencing revealed gene expression changes during repair after acute kidney injury. We describe a small population of proximal tubule cells that fail to repair (FR-PTCs). Since this subpopulation expresses abundant proinflammatory and profibrotic genes, it may represent a new therapeutic target to improve repair and reduce fibrosis after AKI.
Citation impact
617
total citations
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- 42.78
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- 100%
- References
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Authors
5- YKYuhei Kirita
Washington University in St. Louis, Kyoto Prefectural University of Medicine
- HWHao Wu
Washington University in St. Louis
- KUKohei Uchimura
Washington University in St. Louis
- PCParker C. Wilson
Washington University in St. Louis
- BDBenjamin D. HumphreysCorresponding
Washington University in St. Louis
Topics & keywords
Topics
Keywords
- Cell injury
- Acute kidney injury
- Profiling (computer programming)
- Cell biology
- Cell
- Biology
- Computational biology
- Medicine
UN Sustainable Development Goals
- Good health and well-being
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